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What are the main uses of 3 -Hydroxyacetophenone (3-HAP)?
3-Hydroxyacetophenone (3-HAP) has a wide range of uses and is useful in various fields.
In the field of medicine, this is a key intermediate. Due to its unique chemical structure and activity, it can participate in the synthesis of many drugs. For example, some drugs with antibacterial and anti-inflammatory effects, 3-HAP can provide the necessary chemical groups in its preparation process to help build pharmaceutical active ingredients and contribute to human healing and health.
In the field of fragrances, 3-HAP also plays an important role. It emits a unique aroma and can be prepared with fascinating fragrances. In the manufacture of perfumes, cosmetics and other products, with its aroma characteristics, either as a basic fragrance or as an auxiliary ingredient, it blends with other fragrances to create a fresh and elegant, or rich and charming unique fragrance, satisfying the world's diverse pursuit of aroma.
In the field of organic synthesis, 3-HAP is an indispensable raw material. Due to the existence of its activity check point, chemists can modify and expand its structure through various chemical reactions. Synthesize organic compounds with more complex structures and more diverse functions. These compounds may emerge in the field of materials science or serve as new catalysts to promote the continuous development of organic synthetic chemistry and expand the boundaries of human understanding and application of organic substances.
What are the physical properties of 3 -Hydroxyacetophenone (3-HAP)?
3-Hydroxyacetophenone (3-HAP) is one of the organic compounds with special physical properties, which is described in detail today.
First of all, its appearance, under room temperature and pressure, 3-HAP is mostly white to light yellow crystalline powder state, delicate and uniform, and the appearance is quite textured. This form is easy to store and use, and it is convenient in many experimental and industrial processes.
Second describes its melting point, about 79-82 ° C. Melting point is an important physical property of a substance. This specific melting point value not only helps to identify 3-HAP, but also is crucial to control the temperature to achieve its phase transition in the relevant production process. For example, in the purification process, according to the melting point characteristics, precise temperature control can be used to separate impurities to obtain pure 3-HAP.
Furthermore, 3-HAP is slightly soluble in water. Water is a common solvent, and this solubility indicates that in order to disperse 3-HAP in water, special means are required, such as adding appropriate surfactants. However, it is soluble in organic solvents such as ethanol and ether. Organic solvents such as ethanol and ether have unique molecular structures and are compatible with the intermolecular forces of 3-HAP molecules, so they can be miscible. This solubility provides a broad space for their application in organic synthesis, drug preparation and other fields. For example, in drug research and development, 3-HAP can be dissolved in organic solvents, and then uniformly mixed with other drug ingredients to improve the efficacy.
In addition, 3-HAP has a certain degree of volatility. Although the volatility is not strong, it will evaporate slowly in an open system and in a higher temperature environment. This characteristic reminds that when storing and using, proper sealing and temperature control measures should be taken to avoid its volatilization loss and ensure its quality and efficacy.
In summary, the physical properties of 3-HAP, such as appearance, melting point, solubility, volatility, etc., have their own uses, and play a pivotal role in the research and production of chemical, pharmaceutical and other fields.
What are the chemical synthesis methods of 3 '-Hydroxyacetophenone (3-HAP)
The chemical synthesis method of 3-hydroxyacetophenone (3-HAP) is described in detail by you today.
First, the method of using m-hydroxyphenylacetonitrile as the raw material. By co-heating m-hydroxyphenylacetonitrile with acid and hydrolyzing, 3-hydroxyacetophenone can be obtained. This reaction requires attention to the control of reaction temperature and time. If the temperature is too high or the time is too long, it may cause the product to decompose or form by-products.
Second, the method of using m-methoxyacetophenone as the raw material. First, m-methoxyacetophenone is combined with reagents such as hydroiodic acid or boron tribromide to remove the methoxyl group to obtain 3-hydroxyacetophenone. However, hydroiodic acid is highly corrosive, and boron tribromide is also active. It is necessary to be careful during operation, use good ventilation, and take complete protective measures.
Third, acetophenone is used as raw material and is acylated by Fu-g. Using Lewis acids such as aluminum trichloride as catalysts, acetophenone is reacted with acetyl chloride or acetic anhydride to obtain meta-substituted 3-hydroxyacetophenone. However, the selectivity of this reaction is not good, and it is often accompanied by ortho-and para-substituted by-products. The reaction conditions need to be carefully optimized, such as adjusting the amount of catalyst, reaction temperature and solvent type, in order to improve the yield and selectivity of the target product.
There are many methods for synthesizing 3-hydroxyacetophenone, each with advantages and disadvantages. In practical application, the appropriate synthesis path should be carefully selected according to various factors such as raw material availability, cost, yield and purity.
What is the price range of 3 -Hydroxyacetophenone (3-HAP) in the market?
I have not heard of the exact price of 3-hydroxyacetophenone (3-HAP) on the market. The price of this drug often varies with many factors, and it is difficult to hide it in one word.
First, it is related to the price of raw materials. If the raw materials required for its production are expensive and rare, the price of 3-HAP is also high; conversely, if the raw materials are easily available and cheap, the price may drop.
Second, it depends on the simplicity of the process. If the production requires exquisite and complicated methods, labor is expensive and time-consuming, and the cost increases, the price will also follow; if the process is simple, the cost will decrease and the price will also decrease.
Third, the state of market supply and demand has a great impact. If there are many people who want it and there are few people who supply it, the price will rise; if the supply exceeds the demand, the price may fall.
Fourth, the place of production and the enterprise are also related to the price. Different places have different taxes and labor costs; different enterprises have different scales and management methods, resulting in poor prices.
However, if you want to know the approximate market price, you can visit the chemical raw material trading platform, related industry websites, or consult chemical product suppliers. There may be a newer and accurate price range to show the current market price of this drug.
What are the storage conditions for 3 -Hydroxyacetophenone (3-HAP)?
3-Hydroxyacetophenone (3-HAP) is an organic compound. It should be stored in a cool and dry place, away from direct sunlight. Sunlight is a source of heat and energy, but 3-HAP is harmful. Under direct exposure, it may cause it to decompose and deteriorate, damage its chemical properties, and lose its original quality.
Furthermore, the storage place must be well ventilated. Air circulation can dissipate volatile gases that may accumulate. If it is in a closed place, the volatile gas will gradually accumulate, which will increase the risk of fire, and may cause chemical reactions with other substances, endangering the existence of 3-HAP.
Repeated, it should be stored separately with oxidants, acids, bases and other substances. These substances have strong chemical activity and coexist with 3-HAP, which is easy to react violently. Such as oxidizing agents, which have strong oxidizing properties, or oxidize 3-HAP, causing structural changes and properties to change; acids and bases can also interact with certain groups in 3-HAP, resulting in impure compositions and reduced quality.
Also, storage devices are also exquisite. A sealed container should be used, preferably glass or specific plastic materials. Glass is chemically stable and is not easy to interact with 3-HAP; specific plastics can resist its corrosion, and the sealing effect can prevent volatilization and the invasion of external impurities.
In short, if you want to store 3-HAP well, you must follow the rules of cool, dry, well-ventilated, classified storage, and suitable containers, so as to ensure its quality for later use.